Persistent transcriptional programmes are associated with remote memory

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  • 1.

    Kandel, E. R. The molecular biology of memory storage: a dialogue between genes and synapses. Science 294, 1030–1038 (2001).

    ADS  CAS  Article  Google Scholar 

  • 2.

    Flexner, L. B. & Flexner, J. B. Effect of acetoxycycloheximide and of an acetoxycycloheximide–puromycin mixture on cerebral protein synthesis and memory in mice. Proc. Natl Acad. Sci. USA 55, 369–374 (1966).

    ADS  CAS  Article  Google Scholar 

  • 3.

    Alberini, C. M. & Kandel, E. R. The regulation of transcription in memory consolidation. Cold Spring Harb. Perspect. Biol. 7, a021741 (2014).

    Article  Google Scholar 

  • 4.

    Squire, L. R. Mechanisms of memory. Science 232, 1612–1619 (1986).

    ADS  CAS  Article  Google Scholar 

  • 5.

    Kitamura, T. et al. Engrams and circuits crucial for systems consolidation of a memory. Science 356, 73–78 (2017).

    ADS  CAS  Article  Google Scholar 

  • 6.

    DeNardo, L. & Luo, L. Genetic strategies to access activated neurons. Curr. Opin. Neurobiol. 45, 121–129 (2017).

    CAS  Article  Google Scholar 

  • 7.

    DeNardo, L. A. et al. Temporal evolution of cortical ensembles promoting remote memory retrieval. Nat. Neurosci. 22, 460–469 (2019).

    CAS  Article  Google Scholar 

  • 8.

    McKenzie, S. & Eichenbaum, H. Consolidation and reconsolidation: two lives of memories? Neuron 71, 224–233 (2011).

    CAS  Article  Google Scholar 

  • 9.

    Guenthner, C. J., Miyamichi, K., Yang, H. H., Heller, H. C. & Luo, L. Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations. Neuron 78, 773–784 (2013).

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    CAS  Article  Google Scholar 

  • 10.

    Zeisel, A. et al. Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq. Science 347, 1138–1142 (2015).

    ADS  CAS  Article  Google Scholar 

  • 11.

    O’Sullivan, C. N., Sheridan, G. & Murphy, K. in Transcription Factors CREB and NF-κB: Involvement in Synaptic Plasticity and Memory Formation 43–65 (Bentham Science, 2012).

  • 12.

    Suzuki, A. et al. Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J. Neurosci. 31, 8786–8802 (2011).

    CAS  Article  Google Scholar 

  • 13.

    Kida, S. et al. CREB required for the stability of new and reactivated fear memories. Nat. Neurosci. 5, 348–355 (2002).

    CAS  Article  Google Scholar 

  • 14.

    Inuzuka, M., Hayakawa, M. & Ingi, T. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. J. Biol. Chem. 280, 35776–35783 (2005).

    CAS  Article  Google Scholar 

  • 15.

    Zhang, X., Rizo, J. & Südhof, T. C. Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry 37, 12395–12403 (1998).

    CAS  Article  Google Scholar 

  • 16.

    Bélanger, M., Allaman, I. & Magistretti, P. J. Brain energy metabolism: focus on astrocyte–neuron metabolic cooperation. Cell Metab. 14, 724–738 (2011).

    Article  Google Scholar 

  • 17.

    Williamson, L. L., Sholar, P. W., Mistry, R. S., Smith, S. H. & Bilbo, S. D. Microglia and memory: modulation by early-life infection. J. Neurosci. 31, 15511–15521 (2011).

    CAS  Article  Google Scholar 

  • 18.

    Ramilowski, J. A. et al. A draft network of ligand–receptor-mediated multicellular signalling in human. Nat. Commun. 6, 7866 (2015).

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    ADS  CAS  Article  Google Scholar 

  • 19.

    Südhof, T. C. Synaptic neurexin complexes: a molecular code for the logic of neural circuits. Cell 171, 745–769 (2017).

    Article  Google Scholar 

  • 20.

    Saunders, A. et al. Molecular diversity and specializations among the cells of the adult mouse brain. Cell 174, 1015–1030.e16 (2018).

    CAS  Article  Google Scholar 

  • 21.

    Lacar, B. et al. Nuclear RNA-seq of single neurons reveals molecular signatures of activation. Nat. Commun. 7, 11022 (2016).

    ADS  CAS  Article  Google Scholar 

  • 22.

    Cho, J.-H., Huang, B. S. & Gray, J. M. RNA sequencing from neural ensembles activated during fear conditioning in the mouse temporal association cortex. Sci. Rep. 6, 31753 (2016).

    ADS  CAS  Article  Google Scholar 

  • 23.

    Hrvatin, S. et al. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat. Neurosci. 21, 120–129 (2018).

    CAS  Article  Google Scholar 

  • 24.

    Rao-Ruiz, P. et al. Engram-specific transcriptome profiling of contextual memory consolidation. Nat. Commun. 10, 2232 (2019).

    ADS  Article  Google Scholar 

  • 25.

    Zhou, M. et al. A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory. Nat. Neurosci. 21, 1515–1519 (2018).

    CAS  Article  Google Scholar 

  • 26.

    Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9, 171–181 (2014).

    CAS  Article  Google Scholar 

  • 27.

    Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411–420 (2018).

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    CAS  Article  Google Scholar 

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